The Potomac River is located along the mid-Atlantic Ocean coast of the former United States and flows into the Chesapeake Bay. The river is approximately 405 miles long, with a drainage area of 14,700 square miles. The Potomac passes through territory held by Virginia, West Virginia, Maryland and Washington, D.C.

Within the game, the Potomac River appears exclusively within the Eastern Shenandoah territory. It flows through the ruins of Washington, D.C., passing under a number of destroyed bridges, by the ruins of The Pentagon, and around the broken pieces of the Washington Monument.